2-Aminothiophenol → Benzenamine, 2-((1,2,4-oxadiazol-3-ylmethyl)thio)-

HRID 848170노트

반응식

HRID 848170 반응식
[Na].[NH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[SH:9].Cl[CH2:11][C:12]1[N:16]=[CH:15][O:14][N:13]=1>C(O)C>[NH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9][CH2:11][C:12]1[N:16]=[CH:15][O:14][N:13]=1

참가 물질

5

반응물 3

HCID 87132-AminothiophenolHCID 27357653-(Chloromethyl)-1,2,4-oxadiazoleHCID 5360545Sodium

생성물 1

HCID 3057622Benzenamine, 2-((1,2,4-oxadiazol-3-ylmethyl)thio)-

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Sodium (1.27 g; 0.055 mol) was dissolved in absolute ethanol (50 ml) and to this was added 2-aminothiophenol (7.38 g; 0.059 mol). To the resulting solution was added 3-chloromethyl-1,2,4-oxadiazole (6.59 g; 0.055 mol) dropwise over 10 minutes. The resulting mixture was then stirred at ambient temperature for 30 minutes, sodium chloride removed by filtration and the filtrate was evaporated to dryness under reduced pressure to give 3-(2-aminophenylthiomethyl)-1,2,4-oxadiazole which was re-crystallised from isopropanol; m.p. 57°.

후처리

  1. customsodium chloride removed by filtration
  2. customthe filtrate was evaporated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-8a42b7c4c1d94c35863f966d25765d11
출처 데이터셋
uspto-grants-1981_10
특허 번호
US04294843

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