Dimethyl Sulfoxide → HCID 12774893, 화합물

HRID 848637노트

반응식

HRID 848637 반응식
Cl[CH:2]1[CH2:6][CH2:5][O:4][CH:3]1[N:7]1[C:12](=[O:13])[NH:11][C:10](=[O:14])[CH:9]=[N:8]1.CC(C)([O-])C.[K+].CS(C)=O>C(O)(=O)C>[O:4]1[CH2:5][CH:6]=[CH:2][CH:3]1[N:7]1[C:12](=[O:13])[NH:11][C:10](=[O:14])[CH:9]=[N:8]1

참가 물질

5

반응물 3

HCID 679Dimethyl SulfoxideHCID 127749012-(3-Chlorooxolan-2-yl)-1,2,4-triazine-3,5(2H,4H)-dioneHCID 23665647Potassium tert-butoxide

생성물 1

HCID 12774893HCID 12774893, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

2-(3-Chloro-tetrahydro-2-furanyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine (0.8 g) and potassium t-butoxide (0.7 g) are added to dimethyl sulfoxide (3 ml), and the mixture is stirred at room temperature for 3 hours. The reaction mixture is poured into ice-water. The mixture is acidified with acetic acid and extracted with chloroform. The chloroform extract is washed with water, dried and evaporated to remove the solvent. The crude residue is recrystallized from ethanol to give 2-(2,5-dihydro-2-furanyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine (Compound No. 81). Yield, 0.5 g (76%). M.P., 147°-148° C.

후처리

  1. extractionextracted with chloroform
  2. extractionThe chloroform extract
  3. washis washed with water
  4. customdried
  5. customevaporated
  6. customto remove the solvent
  7. customThe crude residue is recrystallized from ethanol

출처 및 근거

ORD 기록
ord-aed1f257c4e94e90b2af6397342a3b5f
출처 데이터셋
uspto-grants-1981_10
특허 번호
US04297129

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