Hydrochloric Acid → 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide trihydrate

HRID 848732노트

반응식

HRID 848732 반응식
Cl.[C:2]([C:5]1[CH:6]=[C:7]([NH:11][CH2:12][C:13]([NH:15][CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([O:26][CH3:27])[CH:19]=2)=[O:14])[CH:8]=[CH:9][CH:10]=1)(=[O:4])[NH2:3].Cl>O>[OH2:4].[OH2:4].[OH2:4].[C:2]([C:5]1[CH:6]=[C:7]([NH:11][CH2:12][C:13]([NH:15][CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([O:26][CH3:27])[CH:19]=2)=[O:14])[CH:8]=[CH:9][CH:10]=1)(=[O:4])[NH2:3]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 156650Benzamide, 3-((2-((2-(3,4-dimethoxyphenyl)ethyl)amino)-2-oxoethyl)amino)-, monohydrochloride

생성물 1

HCID 221497912-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide trihydrate수율 321.6%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 5.0 g of 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide hydrochloride was added 500 ml of water heated at 55° to 60° C. and the mixture was stirred while heating at the same temperature until the hydrochloride completely dissolved. After allowing the mixture to stand overnight, the crystals precipitated were collected by filtration, washed with water and air-dried by allowing to stand at room temperature for 10 days to obtain 4.2 g of 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide trihydrate as colorless needles having a melting point of 53.5°-55.5° C.

후처리

  1. temperatureheated at 55° to 60° C.
  2. dissolutioncompletely dissolved
  3. customthe crystals precipitated
  4. filtrationwere collected by filtration
  5. washwashed with water
  6. customair-dried
  7. waitto stand at room temperature for 10 days

출처 및 근거

ORD 기록
ord-13cae5ef6f70425ca242cc5392d03172
출처 데이터셋
uspto-grants-1981_10
특허 번호
US04297357

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