Hydrochloric Acid → (R)-2-amino-3-(pyridin-2-yl)propanamide hydrochloride

HRID 84881노트

반응식

HRID 84881 반응식
[NH2:1][C:2](=[O:19])[C@H:3]([NH:11]C(=O)OC(C)(C)C)[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1.[ClH:20]>>[ClH:20].[NH2:11][C@H:3]([CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1)[C:2]([NH2:1])=[O:19]

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 67774698(R)-tert-butyl 1-amino-1-oxo-3-(pyridin-2-yl)propan-2-ylcarbamate

생성물 1

HCID 67508637(R)-2-amino-3-(pyridin-2-yl)propanamide hydrochloride

실험 절차

A solution of (R)-tert-butyl 1-amino-1-oxo-3-(pyridin-2-yl)propan-2-ylcarbamate (280 mg, 0.739 mmol) in aq. 6N HCl (8 mL) was stirred at room temperature for 2 h. It was then concentrated in vacuo to give (R)-2-amino-3-(pyridin-2-yl)propanamide hydrochloride (170 mg).

후처리

  1. concentrationIt was then concentrated in vacuo

출처 및 근거

ORD 기록
ord-beec39d9180e4d63b74b5c63d5450de0
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846928B2

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