Thiophosgene → ST50844634

HRID 849041노트

반응식

HRID 849041 반응식
[NH2:1][C:2]1[C:3]([CH3:9])=[N:4][N:5]([CH3:8])[C:6]=1[CH3:7].[C:10](Cl)(Cl)=[S:11]>C(Cl)(Cl)Cl.C([O-])(O)=O.[Na+]>[CH3:8][N:5]1[C:6]([CH3:7])=[C:2]([N:1]=[C:10]=[S:11])[C:3]([CH3:9])=[N:4]1

참가 물질

5

반응물 2

HCID 10040ThiophosgeneHCID 1616031,3,5-trimethyl-1H-pyrazol-4-amine

생성물 1

HCID 3263055ST50844634수율 101.5%

시약·촉매·용매 2

HCID 6212Chloroform용매HCID 516892Sodium Bicarbonate용매

실험 절차

A mixture of 4-amino-1,3,5-trimethylpyrazole (1.32 g, 10.6 mmol) in 50 mL each of CHCl3 and saturated aqueous NaHCO3 was treated dropwise with thiophosgene (0.812 mL, 10.6 mmol) and stirred vigorously for 20 minutes. The layers were separated and the organic phase was washed with brine. After drying (Na2SO4), the solvent was evaporated in vacuo to provide the title compound (1.8 g, brown oil) suitable for use directly in the next step.

후처리

  1. customThe layers were separated
  2. washthe organic phase was washed with brine
  3. dry with materialAfter drying (Na2SO4)
  4. customthe solvent was evaporated in vacuo

출처 및 근거

ORD 기록
ord-774bde4296584d1e9038dff9f6bcffbf
출처 데이터셋
uspto-grants-2000_01
특허 번호
US06011053

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