N,N-Dimethylaniline → 6-Benzylpyridin-2-amine

HRID 849157

반응식

HRID 849157 반응식
[CH2:1]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2-].[Na+].C[N:17](C)C1C=CC=CC=1>>[NH2:17][C:10]1[CH:11]=[CH:12][CH:13]=[C:8]([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[N:9]=1

참가 물질

4

반응물 3

HCID 949N,N-DimethylanilineHCID 75812-(Phenylmethyl)pyridineHCID 24533Sodium amide

생성물 1

HCID 939026-Benzylpyridin-2-amine

실험 절차

Example 298 A) A sample of 2-benzylpyridine (Aldrich, 2.5 g, 0.015 mole), sodium amide (780 mg, 0.02 mole) and N, N-dimethylaniline (25 mL) were refluxed overnight. The contents were allowed to cool and were partitioned between ether and water. The ether layer was dried (MgSO4) and concentrated in vacuo leaving an oil. The oil was purified by chromatography. The purified material was dissolved in 1N HCl, lyophilized, and triturated with EtOAc to give 2-amino-6-benzylpyridine as a white solid.

후처리

  1. temperatureto cool
  2. customwere partitioned between ether and water
  3. dry with materialThe ether layer was dried (MgSO4)
  4. concentrationconcentrated in vacuo
  5. customleaving an oil
  6. customThe oil was purified by chromatography
  7. dissolutionThe purified material was dissolved in 1N HCl
  8. customtriturated with EtOAc

출처 및 근거

ORD 기록
ord-1d26b230ebcc4fa8ac3b368b912322b7
출처 데이터셋
uspto-grants-2000_01
특허 번호
US06011028

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