(2R)-2-bromo-3-hydroxypropanoic acid → HCID 53823235, 화합물

HRID 849373노트

반응식

HRID 849373 반응식
[Br:1][C@H:2]([CH2:6][OH:7])[C:3]([OH:5])=[O:4].[C:8](OC(=N)N(C(C)C)C(C)C)([CH3:11])([CH3:10])[CH3:9]>C(Cl)(Cl)Cl>[Br:1][C@H:2]([CH2:6][OH:7])[C:3]([O:5][C:8]([CH3:11])([CH3:10])[CH3:9])=[O:4]

참가 물질

4

반응물 2

HCID 13776211(2R)-2-bromo-3-hydroxypropanoic acidHCID 22010542tert-Butyl N,N-dipropan-2-ylcarbamimidate

생성물 1

HCID 53823235HCID 53823235, 화합물수율 61%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

18.1 g of (2R)-2-bromo-3-hydroxypropionic acid and 200 ml of chloroform were mixed, and 53.6 g of O-tert-butyl-N,N-diisopropylisourea was added under cooling with ice, followed by stirring at room temperature for 15 hours. Insoluble matters were filtered off, and then, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=10/1→5/1) to obtain 14.7 g (yield: 61%) of the above identified compound as a colorless oily substance.

후처리

  1. temperatureunder cooling with ice
  2. filtrationInsoluble matters were filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate=10/1→5/1)
  5. customto obtain 14.7 g (yield: 61%) of the

출처 및 근거

ORD 기록
ord-93f00563833a486caa1041b9386f716b
출처 데이터셋
uspto-grants-2000_01
특허 번호
US06011174

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