Methyl iodide → (E)-methyl 3-(3-methoxyphenyl)acrylate

HRID 84960노트

반응식

HRID 84960 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5](/[CH:9]=[CH:10]/[C:11]([OH:13])=[O:12])[CH:6]=[CH:7][CH:8]=1.[C:14]([O-])([O-])=O.[K+].[K+].IC>CC(C)=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5](/[CH:9]=[CH:10]/[C:11]([O:13][CH3:14])=[O:12])[CH:6]=[CH:7][CH:8]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 6376683-Methoxycinnamic Acid

생성물 1

HCID 11041597(E)-methyl 3-(3-methoxyphenyl)acrylate

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of (E)-3-(3-methoxyphenyl)acrylic acid (3.56 g, 20 mmol). K2CO3 (3.1 g, 22 mmol), and iodomethane (4.0 g, 28 mmol) in acetone (20 mL) was heated to 70° C. for 16 hours. The mixture was concentrated and partitioned between water and ethyl acetate to afford the crude title compound.

후처리

  1. concentrationThe mixture was concentrated
  2. custompartitioned between water and ethyl acetate

출처 및 근거

ORD 기록
ord-a6285a79c1b34b64965786eeecdd546f
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846951B2

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