Methyl iodide → Quinoline

HRID 849920노트

반응식

C(=O)([O-])[O-].[K+].[K+].[Na].[H][H].CI.C(I)CC.[CH2:16](I)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[CH2:24]([N:26](CC)CC)[CH3:25]>>[N:26]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:25][CH:24]=1

참가 물질

반응물 6

HCID 6328Methyl iodide

HCID 8471Triethylamine

HCID 11430Potassium Carbonate

HCID 12098Benzyl iodide

HCID 336431-Iodopropane

HCID 178506446HCID 178506446, 화합물

생성물 1

HCID 7047Quinoline

실험 절차

To the solution is added one equivalent to a small excess amount of a base, e.g. potassium carbonate, triethylamine, sodium hydrogen, one equivalent to excess amount of halogens alkyl derivative, e.g. methyl iodide, propyl iodide, benzyl iodide, and the mixture is stirred at a temperature of 0° C. to 80° C. to give a quinoline derivative (ivz).

출처 및 근거

ORD 기록: ord-fca95870832c4d87b38e4a935aee1564
출처 데이터셋: uspto-grants-2000_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06015789

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