Sodium Hydroxide → (+-)-2-Amino-2-ethylhex-4-en-1-ol

HRID 850

반응식

HRID 850 반응식
[NH2:1][C:2]([CH2:12][CH3:13])([CH2:8][CH:9]=[CH:10][CH3:11])[C:3](OCC)=[O:4].[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>C1COCC1>[NH2:1][C:2]([CH2:12][CH3:13])([CH2:8][CH:9]=[CH:10][CH3:11])[CH2:3][OH:4]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 54508860(+-)-Ethyl 2-amino-2-ethylhex-4-enoate

생성물 1

HCID 54018667(+-)-2-Amino-2-ethylhex-4-en-1-ol수율 32.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of the product from step (d) (116.7 g) in THF (100 ml) was added to a 1M solution of lithium aluminium hydride in THF (800 ml) at about 0° C. When addition was complete, the mixture was stirred overnight at room temperature, then 50% w/v aqu. NaOH (200 ml) was added. The organic phase was separated, washed with brine, dried and evaporated in vacuo. The residue was distilled to give the desired product as an oil (29.3 g). 1H NMR consistent with the proposed structure.

후처리

  1. additionWhen addition
  2. customThe organic phase was separated
  3. washwashed with brine
  4. customdried
  5. customevaporated in vacuo
  6. distillationThe residue was distilled

출처 및 근거

ORD 기록
ord-8bc8a5b260b5493c8773ed6d142bea7c
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723458

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