Dimethyl Sulfoxide → 4-Formyl-2-methoxybenzoic acid

HRID 850163노트

반응식

HRID 850163 반응식
[OH:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[C:5]([O:12][CH3:13])[CH:4]=1.C(N(CC)CC)C.ClCCl.CS(C)=O>O>[CH:2]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[C:5]([O:12][CH3:13])[CH:4]=1)=[O:1]

참가 물질

6

반응물 4

HCID 679Dimethyl SulfoxideHCID 6344DichloromethaneHCID 8471TriethylamineHCID 212548144-(Hydroxymethyl)-2-methoxybenzoic acid

생성물 1

HCID 212546644-Formyl-2-methoxybenzoic acid

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

To a mixture of 4-hydroxymethyl-2-methoxybenzoic acid (1.5 g), triethylamine (5 g), dichloromethane (3 ml) and dimethyl sulfoxide (3 ml) was added portionwise sulfur trioxide pyridine complex (3.93 g) in water bath, and the mixture was stirred for 1.5 hours at the same temperature. The reaction mixture was poured into water and extracted with dichloromethane. The organic layer was washed with water and brine, dried over magnesium sulfate and evaporated in vacuo to give 4-formyl-2-methoxybenzoic acid.

후처리

  1. extractionextracted with dichloromethane
  2. washThe organic layer was washed with water and brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-67205a2f8f3940028afd417ff55e1db5
출처 데이터셋
uspto-grants-2000_01
특허 번호
US06015818

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