Ammonia → Coniferyl Alcohol

HRID 850265

반응식

HRID 850265 반응식
S(=O)(=O)(O)O.N.[C:7]1([O:17][CH3:18])[C:8](=[CH:10][CH:11]=[C:12]([CH:16]=1)[CH2:13][CH:14]=[CH2:15])[OH:9].C[N+]1C2C(=CC=CC=2)N=C2C=1C=CC=C2.C[O:35]S([O-])(=O)=O>CCCCCCCC.O>[CH2:15]([OH:35])/[CH:14]=[CH:13]/[C:12]1[CH:11]=[CH:10][C:8]([OH:9])=[C:7]([O:17][CH3:18])[CH:16]=1

참가 물질

7

반응물 4

HCID 222AmmoniaHCID 1118Sulfuric AcidHCID 3314EugenolHCID 9285Phenazine Methosulfate

생성물 1

HCID 1549095Coniferyl Alcohol

시약·촉매·용매 2

HCID 356Octane용매HCID 962Water용매

실험 절차

A dilute sulfuric acid solution or aqueous ammonia was dropwise added to the foregoing reaction solution for enzyme-activity determination from which the buffer is omitted (i.e., a solution comprising 50 μl of a 200 mM solution of eugenol in n-octane, 200 μl of a 50 mM aqueous solution of phenazine methosulfate and 675 μl of deionized water) to adjust the pH thereof from 5 to 7 and the resulting mixture is stirred at a temperature ranging from 25 to 55° C. for 15 to 180 minutes. After the completion of the reaction, the coniferyl alcohol is extracted from the reaction solution with an organic solvent such as ethyl acetate, chloroform, methylene chloride or ethyl ether, followed by purification thereof by a means such as silica gel chromatography, reverse phase liquid chromatography or vacuum distillation, optional discoloration with active carbon and vacuum drying to give colorless coniferyl alcohol powder.

후처리

  1. customAfter the completion of the reaction
  2. extractionthe coniferyl alcohol is extracted from the reaction solution with an organic solvent such as ethyl acetate, chloroform, methylene chloride or ethyl ether
  3. customfollowed by purification
  4. distillationphase liquid chromatography or vacuum distillation, optional discoloration with active carbon and vacuum
  5. customdrying

출처 및 근거

ORD 기록
ord-a3ba7078a66245e2acd24ba8e7037606
출처 데이터셋
uspto-grants-2000_01
특허 번호
US06017724

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