Benzoyl Peroxide → HCID 54161484, 화합물

HRID 850335노트

반응식

HRID 850335 반응식
[C:1]([O:5][C:6](=[O:23])[CH2:7][C:8]1[CH:13]=[C:12]([C:14]([CH3:17])([CH3:16])[CH3:15])[C:11]([OH:18])=[C:10]([C:19]([CH3:22])([CH3:21])[CH3:20])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[Br:24]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[C:1]([O:5][C:6](=[O:23])[CH:7]([C:8]1[CH:9]=[C:10]([C:19]([CH3:22])([CH3:21])[CH3:20])[C:11]([OH:18])=[C:12]([C:14]([CH3:17])([CH3:16])[CH3:15])[CH:13]=1)[Br:24])([CH3:3])([CH3:4])[CH3:2]

참가 물질

5

반응물 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 53661891HCID 53661891, 화합물

생성물 1

HCID 54161484HCID 54161484, 화합물

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

반응 조건

온도
60 °C

실험 절차

To a solution of Intermediate 18 (1.0314 g, 3.22 mmol) in 7.3 mL CCl4 was added N-bromosuccinimide (0.5827 g) and a catalytic amount of benzoyl peroxide. The reaction was heated to 60° C. overnight. The solvent was removed in vacuo. The residue was taken up in ethyl acetate, washed with water and brine, dried over MgSO4, and concentrated to an orange oil (0.8654 g, 2.17 mmol), which was used in the next step without further purification.

후처리

  1. customThe solvent was removed in vacuo
  2. washwashed with water and brine
  3. dry with materialdried over MgSO4
  4. customwas used in the next step without further purification

출처 및 근거

ORD 기록
ord-0ce330ad76c646dd803ca64e3cbe2446
출처 데이터셋
uspto-grants-2000_01
특허 번호
US06017918

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