2-(3-(Benzyloxy)phenyl)ethanamine → m-Tyramine

HRID 850456

반응식

HRID 850456 반응식
C([O:8][C:9]1[CH:10]=[C:11]([CH2:15][CH2:16][NH2:17])[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1.[H][H]>[C].[Pd].C1COCC1>[OH:8][C:9]1[CH:10]=[C:11]([CH2:15][CH2:16][NH2:17])[CH:12]=[CH:13][CH:14]=1

참가 물질

5

반응물 2

HCID 2074152-(3-(Benzyloxy)phenyl)ethanamineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 11492m-Tyramine수율 95.5%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 8028Tetrahydrofuran용매

실험 절차

10% Palladium-carbon catalyst (water content 50%, 86 mg) was added to a solution of 2-(3-benzyloxyphenyl)ethylamine (434 mg, 1.91 mmol, 1.0 eq) in THF (10 ml), and the mixture was stirred at room temperature for 3 hours in a stream of hydrogen. The reaction ma ire was filtered through Celite, and the filtrate was concentrated under reduced pressure to give 2-(3-hydroxyphenyl)ethylamine (250 mg, 95.5%).

후처리

  1. filtrationThe reaction ma ire was filtered through Celite
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-a43b55be186346cb9f598980f7df62eb
출처 데이터셋
uspto-grants-2000_01
특허 번호
US06017919

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