4-Benzyloxybenzylamine → 4-Hydroxybenzylamine

HRID 850463

반응식

HRID 850463 반응식
C([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][NH2:14])=[CH:11][CH:10]=1)C1C=CC=CC=1.[H][H]>[C].[Pd].C1COCC1>[OH:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][NH2:14])=[CH:11][CH:10]=1

참가 물질

5

반응물 2

HCID 42928454-BenzyloxybenzylamineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 974724-Hydroxybenzylamine수율 85%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 8028Tetrahydrofuran용매

실험 절차

10% Palladium-carbon catalyst (water content 50%, 50 mg) was added to a solution of 4-benzyloxybenzylamine (530 mg, 2.485 mmol, 1.0 eq) in THF (10 ml), and the mixture was stirred for 3 hours at room temperature in a stream of hydrogen. The reaction mixture was filtered through Celite, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by column chromatography (n-hexane/ethyl acetate=1/1) to give 4-hydroxybenzylamine (260 mg, 85.0%).

후처리

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe obtained residue was purified by column chromatography (n-hexane/ethyl acetate=1/1)

출처 및 근거

ORD 기록
ord-cb6bd5b742c84021a56ca1cda3c9581f
출처 데이터셋
uspto-grants-2000_01
특허 번호
US06017919

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