Sodium Hydroxide → Sodium 2-(2,1,3-benzothiadiazol-5-yl)-3-benzyl-4-(4-methoxyphenyl)-4-oxo-2-butenoate

HRID 850638노트

반응식

HRID 850638 반응식
[OH-].[Na+:2].[N:3]1[S:4][N:5]=[C:6]2[CH:11]=[C:10]([C:12]3[C:13](=[O:33])[O:14][C:15]([OH:32])([C:24]4[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=4)[C:16]=3[CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH:9]=[CH:8][C:7]=12>CO>[N:3]1[S:4][N:5]=[C:6]2[CH:11]=[C:10]([C:12](=[C:16]([CH2:17][C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[C:15]([C:24]3[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=3)=[O:32])[C:13]([O-:33])=[O:14])[CH:9]=[CH:8][C:7]=12.[Na+:2]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 154104553-(2,1,3-Benzothiadiazol-5-yl)-4-benzyl-5-hydroxy-5-(4-methoxy-phenyl)-5H-furan-2-one

생성물 1

HCID 74088571Sodium 2-(2,1,3-benzothiadiazol-5-yl)-3-benzyl-4-(4-methoxyphenyl)-4-oxo-2-butenoate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

0.7 ml of 0.1 N NaOH is added to a suspension of 30 mg of 3-(2,1,3-benzothiadiazol-5-yl)-4-benzyl-5-hydroxy-5-(4-methoxyphenyl)-5H-furan-2-one in 1 ml of methanol and the mixture is stirred at room temperature. The solvent is removed, the residue is partitioned between water and diethyl ether, and the agueous phase is then lyophilized. Sodium 2-(2,1,3-benzothiadiazol-5-yl)-3-benzyl-4-(4-methoxyphenyl)-4-oxo-2-butenoate, FAB 453, is obtained.

후처리

  1. customThe solvent is removed
  2. customthe residue is partitioned between water and diethyl ether

출처 및 근거

ORD 기록
ord-c1971befad4846e1872dd28a073ccee5
출처 데이터셋
uspto-grants-2000_01
특허 번호
US06017939

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