Sodium Hydroxide → 10-bromo-5-carboxy-2-methoxy-4H-pyrido[3,2,1-jk]carbazole-4-one

HRID 850778노트

반응식

HRID 850778 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]3[CH:19]=[C:18]([C:20]([O:22]CC)=[O:21])[C:17](=[O:25])[C:8]4[CH:9]=[C:10]([O:15][CH3:16])[CH:11]=[C:12]([C:13]=2[CH:14]=1)[C:7]3=4.[OH-].[Na+]>C(O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]3[CH:19]=[C:18]([C:20]([OH:22])=[O:21])[C:17](=[O:25])[C:8]4[CH:9]=[C:10]([O:15][CH3:16])[CH:11]=[C:12]([C:13]=2[CH:14]=1)[C:7]3=4

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 2125285710-bromo-5-ethoxycarbonyl-2-methoxy-4H-pyrido [3,2,1-jk]carbazole-4-one

생성물 1

HCID 2125282410-bromo-5-carboxy-2-methoxy-4H-pyrido[3,2,1-jk]carbazole-4-one수율 83.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

10-bromo-5-ethoxycarbonyl-2-methoxy-4H-pyrido[3,2,1-jk]carbazole-4-one (400 mg) obtained in Example 98 was suspended in ethanol (10 ml), and 1N sodium hydroxide (3 ml) was added. The mixture was stirred at room temperature for 12 hours, and the solvent was evaporated under reduced pressure. To the residue was added 1N hydrochloric acid to pH 1, and the crystals precipitated were recovered by filtration, and washed with ethanol and ether to obtain the title compound (310 mg, 83%).

후처리

  1. customthe solvent was evaporated under reduced pressure
  2. additionTo the residue was added 1N hydrochloric acid to pH 1
  3. customthe crystals precipitated
  4. filtrationwere recovered by filtration
  5. washwashed with ethanol and ether

출처 및 근거

ORD 기록
ord-eb1ca7c767a94670b4a82836f5b06137
출처 데이터셋
uspto-grants-2000_01
특허 번호
US06018046

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