Sodium Hydroxide → 1,1-Dimethylethyl N-[(1S,2S,4S)-4-amino-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]carbamate

HRID 850857노트

반응식

HRID 850857 반응식
C(O)(=O)C(O)=O.[C:7]([O:11][C:12]([NH:14][C@H:15]([C@@H:23]([OH:34])[CH2:24][C@@H:25]([NH2:33])[CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:13])([CH3:10])([CH3:9])[CH3:8].[OH-].[Na+]>C1(C)C=CC=CC=1>[C:7]([O:11][C:12]([NH:14][C@H:15]([C@@H:23]([OH:34])[CH2:24][C@@H:25]([NH2:33])[CH2:26][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)[CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)=[O:13])([CH3:10])([CH3:8])[CH3:9]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 70191891HCID 70191891, 화합물

생성물 1

HCID 103178781,1-Dimethylethyl N-[(1S,2S,4S)-4-amino-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]carbamate

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

(2S,3S,5S)-2-tert-Butoxycarbonylamino-3-hydroxy-5-amino-1,6-diphenylhexane oxalate (500 mg, 1.05 mmol) obtained in Example 43 (A) was suspended in toluene (5 ml). An aqueous solution (5 ml) of NaOH (200 mg) was added thereto and the mixture was vigorously stirred, then separated. The organic layer was washed with water and dried over anhydrous magnesium sulfate. The desiccant was filtered off, and the filtrate was concentrated to give the desired compound as colorless crystals. Yield: 340 mg (84%).

후처리

  1. customseparated
  2. washThe organic layer was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. filtrationThe desiccant was filtered off
  5. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-46a79619164e4a008046c648909a75d9
출처 데이터셋
uspto-grants-2000_01
특허 번호
US06018069

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