Sodium Hydroxide → 2-Carbamyl-4-hexadecylaminothiophene

HRID 850961노트

반응식

HRID 850961 반응식
[CH2:1]([NH:17][C:18]1[CH:19]=[C:20]([C:23]#[N:24])[S:21][CH:22]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[OH-:25].[Na+]>COCCO>[C:23]([C:20]1[S:21][CH:22]=[C:18]([NH:17][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[CH:19]=1)(=[O:25])[NH2:24]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 131349914-Hexadecylamino-2-cyanothiophene

생성물 1

HCID 131349932-Carbamyl-4-hexadecylaminothiophene

시약·촉매·용매 1

HCID 80192-Methoxyethanol용매

실험 절차

A mixture of 6.9 g. of 4-hexadecylamino-2-cyanothiophene, 80 ml. of methyl cellosolve, and 80 ml. of 1 N sodium hydroxide is refluxed for 21 hours. After cooling in an ice bath, the solid is filtered and thoroughly washed with methylene chloride. The solid is then added to 100 ml. of water and 5 ml. of concentrated hydrochloric acid and stirred for 8 hours. The solid is filtered and recrystallized from isopropanol.

후처리

  1. additionA mixture of 6.9 g
  2. temperatureAfter cooling in an ice bath
  3. filtrationthe solid is filtered
  4. washthoroughly washed with methylene chloride
  5. additionThe solid is then added to 100 ml
  6. filtrationThe solid is filtered
  7. customrecrystallized from isopropanol

출처 및 근거

ORD 기록
ord-b644d3a0e3614ba791118f70976f2154
출처 데이터셋
uspto-grants-1983_05
특허 번호
US04382143

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