Hydrochloric Acid → 4-Hexadecylamino-2-thiophenecarboxylic acid

HRID 850962노트

반응식

HRID 850962 반응식
[C:1]([C:4]1[S:5][CH:6]=[C:7]([NH:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[CH:8]=1)(=[O:3])N.Cl.C[O:28]CCO>>[CH2:10]([NH:9][C:7]1[CH:8]=[C:4]([C:1]([OH:28])=[O:3])[S:5][CH:6]=1)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 80192-MethoxyethanolHCID 131349932-Carbamyl-4-hexadecylaminothiophene

생성물 1

HCID 131349944-Hexadecylamino-2-thiophenecarboxylic acid

실험 절차

A mixture of 4.4 g. of 2-carbamyl-4-hexadecylaminothiophene, 50 ml. of methyl cellosolve, and 50 ml. of 6 N hydrochloric acid is refluxed for 40 hours and then allowed to cool. The solid is filtered and recrystallized from methanol. The solid is then dissolved in hot sodium bicarbonate solution, filtered, and the filtrate is acidified with concentrated hydrochloric acid. The resulting precipitate is collected and recrystallized from isopropanol to yield the product.

후처리

  1. additionA mixture of 4.4 g
  2. temperatureto cool
  3. filtrationThe solid is filtered
  4. customrecrystallized from methanol
  5. dissolutionThe solid is then dissolved in hot sodium bicarbonate solution
  6. filtrationfiltered
  7. customThe resulting precipitate is collected
  8. customrecrystallized from isopropanol
  9. customto yield the product

출처 및 근거

ORD 기록
ord-77c3e18d0c7043d184750298c932b43d
출처 데이터셋
uspto-grants-1983_05
특허 번호
US04382143

반응 노트

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