4-Bromophenol → HCID 70531710, 화합물

HRID 851064노트

반응식

HRID 851064 반응식
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][C@@H:9]([OH:12])[C@H:8]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:7]1)=[O:5])[CH3:2].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[Br:38][C:39]1[CH:44]=[CH:43][C:42](O)=[CH:41][CH:40]=1.N(C(OCC)=O)=NC(OCC)=O>C1C=CC=CC=1>[Br:38][C:39]1[CH:44]=[CH:43][C:42]([O:12][C@H:9]2[CH2:10][CH2:11][N:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:7][C@H:8]2[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)=[CH:41][CH:40]=1

참가 물질

6

반응물 4

HCID 78084-BromophenolHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 13039299HCID 13039299, 화합물

생성물 1

HCID 70531710HCID 70531710, 화합물

시약·촉매·용매 1

HCID 241Benzene용매2회

실험 절차

To a stirred solution of 6.26 g of trans-1-ethoxycarbonyl-3-phenyl-4-piperidinol, 7.21 g of triphenylphosphine, 4.76 g of 4-bromophenol and 250 ml of benzene is added dropwise, at 5° C. under nitrogen, a solution of 4.79 g of diethyl azocarboxylate in 250 ml of benzene. After the addition is complete, the mixture is stirred at room temperature overnight. The reaction mixture is processed according to the procedure of Example 75 to give product as a gum.

후처리

  1. additionAfter the addition
  2. customto give product as a gum

출처 및 근거

ORD 기록
ord-b048820bfa974806ac8da41578010a07
출처 데이터셋
uspto-grants-1983_05
특허 번호
US04382141

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