Potassium Iodide → 2-Acetonyloxy-4-chloro-3-fluoronitrobenzene

HRID 851083노트

반응식

HRID 851083 반응식
[Cl:1][C:2]1[C:3]([F:12])=[C:4]([OH:11])[C:5]([N+:8]([O-:10])=[O:9])=[CH:6][CH:7]=1.Cl[CH2:14][C:15](=[O:17])[CH3:16].[I-].[K+]>CC(C)=O>[CH2:14]([O:11][C:4]1[C:3]([F:12])=[C:2]([Cl:1])[CH:7]=[CH:6][C:5]=1[N+:8]([O-:10])=[O:9])[C:15]([CH3:16])=[O:17]

참가 물질

5

반응물 3

HCID 4875Potassium IodideHCID 6571ChloroacetoneHCID 131885853-Chloro-2-fluoro-6-nitrophenol

생성물 1

HCID 131885862-Acetonyloxy-4-chloro-3-fluoronitrobenzene수율 54.5%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 3 g (15.7 mmols) of 3-chloro-2-fluoro-6-nitrophenol, 3 ml of chloroacetone and 300 mg of potassium iodide in 50 ml of acetone was refluxed for 6 hours while vigorously stirring. After cooling, any insoluble substance was removed by filtration, and the filtrate was concentrated and purified by silica gel (20 g) column chromatography using chloroform as an eluant to provide 2.5 g (54.5% yield) of 2-acetonyloxy-4-chloro-3-fluoronitrobenzene as an oil.

후처리

  1. temperaturewas refluxed for 6 hours
  2. temperatureAfter cooling
  3. customany insoluble substance was removed by filtration
  4. concentrationthe filtrate was concentrated
  5. custompurified by silica gel (20 g) column chromatography

출처 및 근거

ORD 기록
ord-e7ae9a4e404c437991836646a990e61b
출처 데이터셋
uspto-grants-1983_05
특허 번호
US04382892

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