Water → 4-(Dimethylaminomethyl)-2-thiophenemethanol

HRID 851104노트

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HRID 851104 반응식
[OH:1][CH2:2][C:3]1[S:7][CH:6]=[C:5]([C:8]([N:10]([CH3:12])[CH3:11])=O)[CH:4]=1.[H-].[Al+3].[H-].[H-].O>O1CCCC1.Cl>[CH3:12][N:10]([CH2:8][C:5]1[CH:4]=[C:3]([CH2:2][OH:1])[S:7][CH:6]=1)[CH3:11]

참가 물질

6

반응물 3

HCID 962WaterHCID 212890685-(Hydroxymethyl)-N,N-dimethyl-3-thiophenecarboxamideHCID 21584524Aluminiumhydride

생성물 1

HCID 129265384-(Dimethylaminomethyl)-2-thiophenemethanol

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of 5-(hydroxymethyl)-N,N-dimethyl-3-thiophenecarboxamide (1.7 g) in dry tetrahydrofuran (150 ml) was treated with a 0.5 M solution of aluminium hydride in tetrahydrofuran (26 ml). After 2 h at room temperature, water (5 ml) was cautiously added and the mixture was filtered through diatomaceous earth. The filtrate was evaporated to leave an oily residue, which was dissolved in 2 M hydrochloric acid (20 ml). The aqueous solution was washed with diethyl ether, basified with 5 M sodium hydroxide and extracted with ethyl acetate.

후처리

  1. filtrationthe mixture was filtered through diatomaceous earth
  2. customThe filtrate was evaporated
  3. customto leave an oily residue, which
  4. washThe aqueous solution was washed with diethyl ether
  5. extractionextracted with ethyl acetate

출처 및 근거

ORD 기록
ord-0d89dcde9c6e498190a3e7dd5a2c5d76
출처 데이터셋
uspto-grants-1983_05
특허 번호
US04382929

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