3-Bromo-1-propanol → 1-[4-(3-Hydroxypropyloxy)phenyl]propan-2-one
반응식
C1[O:14][C:4]([CH3:13])([CH2:5][C:6]2[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=2)OC1.[OH-].[Na+].Br[CH2:18][CH2:19][CH2:20][OH:21]>O>[OH:21][CH2:20][CH2:19][CH2:18][O:12][C:9]1[CH:8]=[CH:7][C:6]([CH2:5][C:4](=[O:14])[CH3:13])=[CH:11][CH:10]=1참가 물질
5
실험 절차
1-(4-Hydroxyphenyl)propan-2-one ethylene ketal (3.88 g) was added to a solution of sodium hydroxide (1.5 g) in water (30 ml) and the mixture was stirred at room temperature for 30 minutes. 1-Bromo-3-hydroxypropane (2.98 g) was added and the mixture was boiled under reflux with stirring for 11/2 hours. After cooling water (50 ml) was added, the mixture was extracted with ether, the extracts dried (MgSO4) and evaporated to give the title compound (3.94 g) as its ethylene ketal.
후처리
- temperatureunder reflux
- stirringwith stirring for 11/2 hours
- additionwas added
- extractionthe mixture was extracted with ether
- dry with materialthe extracts dried (MgSO4)
- customevaporated
출처 및 근거
- ORD 기록
- ord-f9fb21408b294431a90c83cd983e6cf7
- 출처 데이터셋
- uspto-grants-1983_05
- 특허 번호
- US04382958
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