Chloroacetone → HCID 13136935, 화합물

HRID 851202노트

반응식

HRID 851202 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3[CH2:13][CH2:12][NH:11][CH2:10][C:9]=3[C:14](=[O:16])[O:15][C:4]=2[CH:3]=1.C(N(CC)CC)C.Cl[CH2:25][C:26](=[O:28])[CH3:27]>C(O)C>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3[CH2:13][CH2:12][N:11]([CH2:25][C:26](=[O:28])[CH3:27])[CH2:10][C:9]=3[C:14](=[O:16])[O:15][C:4]=2[CH:3]=1

참가 물질

5

반응물 3

HCID 6571ChloroacetoneHCID 8471TriethylamineHCID 106087088-Methyl-1,2,3,4-tetrahydro-chromeno[3,4-c]pyridin-5-one

생성물 1

HCID 13136935HCID 13136935, 화합물수율 77.8%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 1,2,3,4-tetrahydro-8-methyl-5H-[1]benzopyrano[3,4-c]pyridin-5-one (2.0 g, 0.009 moles), triethylamine (1.4 ml, 0.010 moles), and 1-chloro-2-propanone (0.8 g, 0.009 moles) in ethanol (50 ml) is stirred and heated to reflux. After 20 hours the mixture is cooled and the precipitate filtered off, rinsed with ethanol, and dried to give the product (1.9 g), mp 128°-129° C.

후처리

  1. temperatureheated to reflux
  2. temperatureAfter 20 hours the mixture is cooled
  3. filtrationthe precipitate filtered off
  4. washrinsed with ethanol
  5. customdried

출처 및 근거

ORD 기록
ord-82ed3702c3be401f94e157ca06656e99
출처 데이터셋
uspto-grants-1983_05
특허 번호
US04382939

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