Hydrochloric Acid → H-Nva-Met-NH2.HCl

HRID 851723노트

반응식

HRID 851723 반응식
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:6]([NH:8][C@H:9]([C:14]([NH2:16])=[O:15])[CH2:10][CH2:11][S:12][CH3:13])=[O:7])[CH2:3][CH2:4][CH3:5].[ClH:24]>C(OCC)(=O)C.CCOCC>[NH2:1][C@H:2]([C:6]([NH:8][C@H:9]([C:14]([NH2:16])=[O:15])[CH2:10][CH2:11][S:12][CH3:13])=[O:7])[CH2:3][CH2:4][CH3:5].[ClH:24]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 57006973BOC-Nva-Met-NH2

생성물 1

HCID 88736758H-Nva-Met-NH2.HCl수율 89%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8857Ethyl Acetate용매2회

실험 절차

4.5 g (13 mmoles) of BOC-Nva-Met-NH2 are suspended in 20 ml of ethyl acetate, and 20 ml of a 6 n hydrochloric acid solution in ethyl acetate are added to the suspension. After one hour of standing the reaction mixture is diluted with ether, the separated precipitate is filtered off, and dried in vacuo over anhydrous sodium hydroxide. The resulting 4 g of crude product are recrystallized from a mixture of methanol and ether. 3.28 g (89%) of H-Nva-Met-NH2.HCl are obtained; m.p.: 198°-200° C., Rf5 =0.40, [α]D25 =+10.2° (c=1%, in methanol).

후처리

  1. filtrationthe separated precipitate is filtered off
  2. dry with materialdried in vacuo over anhydrous sodium hydroxide
  3. customThe resulting 4 g of crude product are recrystallized from a mixture of methanol and ether

출처 및 근거

ORD 기록
ord-76928549785c412ea2c9bc34b93953ca
출처 데이터셋
uspto-grants-1983_05
특허 번호
US04386073

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