Dimethyl Sulfoxide → HCID 54150769, 화합물

HRID 851809노트

반응식

HRID 851809 반응식
C[O-].[Na+].CO.C1(S([CH2:15][CH2:16][CH2:17][CH:18]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][C:19]2=O)(=O)=O)C=CC=CC=1.CS(C)=O>C1(C)C=CC=CC=1>[C:18]12[CH2:17][CH2:16][CH:15]=[C:19]1[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH:29]=2

참가 물질

6

반응물 4

HCID 679Dimethyl SulfoxideHCID 887MethanolHCID 10942334Sodium MethoxideHCID 205012032-[3-(Benzenesulfonyl)propyl]cyclododecan-1-one

생성물 1

HCID 54150769HCID 54150769, 화합물수율 76%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

2.37 ml of a 30% solution of sodium methoxide in methyl alcohol (10.2 mmole) were added dropwise to a solution of 0.728 g (2.0 mmole) of 2-(3-phenylsulfonyl-prop-1-yl)-cyclododecanone in 10 ml of toluene as indicated sub letter (b). After 90 min. of heating, 0.57 ml (8.0 mmole) of dimethylsulfoxide (DMSO) were added to the reaction mixture which was then heated to reflux for 4 further hours. After extraction and distillation, there were isolated 0.310 g (76% yield) of the desired compound.

후처리

  1. temperatureAfter 90 min. of heating
  2. temperaturewas then heated
  3. temperatureto reflux for 4 further hours
  4. extractionAfter extraction and distillation

출처 및 근거

ORD 기록
ord-4d778dacf7734d94b67b18c12140ad03
출처 데이터셋
uspto-grants-1983_05
특허 번호
US04386220

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