Dimethyl Sulfoxide → HCID 54150769, 화합물

HRID 851810노트

반응식

HRID 851810 반응식
C1(S([CH2:10][CH2:11][CH2:12][CH:13]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][C:14]2=O)(=O)=O)C=CC=CC=1.[OH-].[K+].CS(C)=O>C1(C)C=CC=CC=1>[C:13]12[CH2:12][CH2:11][CH:10]=[C:14]1[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH:24]=2

참가 물질

5

반응물 3

HCID 679Dimethyl SulfoxideHCID 14797Potassium HydroxideHCID 205012032-[3-(Benzenesulfonyl)propyl]cyclododecan-1-one

생성물 1

HCID 54150769HCID 54150769, 화합물수율 87%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

10.92 g (0.03 mole) of 2-(3-phenylsulfonyl-prop-1-yl)-cyclododecanone and 11.0 g (0.197 mole) of freshly powdered KOH in 40 ml of toluene were heated to reflux for 30 min. as indicated sub letter (b). After addition of 6 ml (0.085 mole) of DMSO, the reaction mixture was heated to reflux for 12 further hours, then cooled, extracted and finally distilled as indicated hereinabove to afford 5.32 g (87% yield) of the desired compound.

후처리

  1. temperaturethe reaction mixture was heated
  2. temperatureto reflux for 12 further hours
  3. temperaturecooled
  4. extractionextracted
  5. distillationfinally distilled

출처 및 근거

ORD 기록
ord-65a0dc51fbae409c8f02de375a63e6c5
출처 데이터셋
uspto-grants-1983_05
특허 번호
US04386220

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