Quinoline → 5-Decenoic acid

HRID 851837

반응식

HRID 851837 반응식
Br[CH:2]([CH2:11][CH2:12][CH2:13][CH3:14])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9]C)=[O:8].N1C2C(=CC=CC=2)C=CC=1.C(OC)(=O)CCCC=CCCCC.C(OC)(=O)CCCCC=CCCC.C(O)(=O)CCCCC=CCCC>>[C:7]([OH:9])(=[O:8])[CH2:6][CH2:5][CH2:4][CH:3]=[CH:2][CH2:11][CH2:12][CH2:13][CH3:14]

참가 물질

6

반응물 5

HCID 7047QuinolineHCID 22931398Methyl 6-bromodecanoateHCID 53401195Dec-6-enoic acidHCID 53854285HCID 53854285, 화합물HCID 54534253Methyl 5-decenoate

생성물 1

HCID 534008795-Decenoic acid수율 35%

실험 절차

Methyl 6-bromodecanoate (1.2 g) and quinoline (1.2g) were mixed together, and then allowed to react at 240° C. for 5 minutes. After the reaction was completed, the reaction solution was extracted with ether, washed with dilute sulfuric acid, washed with water, dried, evaporated to remove the solvent, and then distilled, thereby giving a mixture of methyl 5-decenoate and methyl 6-decenoate (310 mg). The mixture was hydrolyzed in a coventional manner, thereby giving a mixture (270 mg) of 5-decenoic acid and 6-decenoic acid (1/1).

후처리

  1. customto react at 240° C. for 5 minutes
  2. extractionthe reaction solution was extracted with ether
  3. washwashed with dilute sulfuric acid
  4. washwashed with water
  5. customdried
  6. customevaporated
  7. customto remove the solvent
  8. distillationdistilled
  9. customgiving

출처 및 근거

ORD 기록
ord-8dd77bdcdc434d79a2d242b7afbf50d2
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07252849B2

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