Hydrazine hydrate (1:1) → HCID 69414151, 화합물

HRID 851891노트

반응식

HRID 851891 반응식
[O:1]=[S:2]1(=[O:26])[C:7]2[CH:8]=[C:9]([O:12][C:13]3[CH:14]=[C:15]([CH:20]=[CH:21][CH:22]=3)[C:16](OC)=[O:17])[CH:10]=[CH:11][C:6]=2[N:5]2[CH2:23][CH2:24][CH2:25][C:4]2=[N:3]1.O.[NH2:28][NH2:29]>CO.CN(C=O)C>[O:1]=[S:2]1(=[O:26])[C:7]2[CH:8]=[C:9]([O:12][C:13]3[CH:14]=[C:15]([CH:20]=[CH:21][CH:22]=3)[C:16]([NH:28][NH2:29])=[O:17])[CH:10]=[CH:11][C:6]=2[N:5]2[CH2:23][CH2:24][CH2:25][C:4]2=[N:3]1

참가 물질

5

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 69414424HCID 69414424, 화합물

생성물 1

HCID 69414151HCID 69414151, 화합물

시약·촉매·용매 2

HCID 887Methanol용매HCID 6228Dimethylformamide용매

실험 절차

A suspension of 500 mg (1.34 mmol) of the product obtained in Step A and 978 μl (20.13 mmol) of hydrazine monohydrate in a mixture of MeOH (30 ml) and DMF (6 ml) is refluxed for 24 hours. The MeOH is evaporated off, water is added to the reaction mixture and the precipitate, which corresponds to the title product, is filtered off.

후처리

  1. temperatureis refluxed for 24 hours
  2. customThe MeOH is evaporated off
  3. additionwater is added to the reaction mixture
  4. filtrationis filtered off

출처 및 근거

ORD 기록
ord-862ff0c4f81b44cbb184e5c07dd910c3
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07253163B2

반응 노트

불러오는 중…