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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 85190생성일: 2026년 10월 26일

4-(Pyrrolidin-1-ylmethyl)aniline → 2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-N-(4-(pyrrolidin-1-ylmethyl)phenyl)-1H-benzo[d]imidazole-4-carboxamide

https://huagongshe.com/reaction/85190

반응식

참여 물질

역할이름HCID투입량
반응물4-(Pyrrolidin-1-ylmethyl)anilineHCID 776852—
반응물2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole-4-carboxylic acidHCID 67202138—
생성물2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-N-(4-(pyrrolidin-1-ylmethyl)phenyl)-1H-benzo[d]imidazole-4-carboxamideHCID 67201704—

반응 단계

2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole-4-carboxylic acid 159 was coupled with 4-(pyrrolidin-1-ylmethyl)aniline 160 to produce 2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-N-(4-(pyrrolidin-1-ylmethyl)phenyl)-1H-benzo[d]imidazole-4-carboxamide (Compound 869) using the same general procedure outlined in Example 39. MS (ESI) calcd for C31H32F3N5O: 547.26; found: 548 [M+H].

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08846947B2
출처 데이터셋uspto-grants-2014_09
ORD IDord-0539bb62776c46c1a37ae3165f4815f2
출처 메모uspto-grants-2014_09