Ethanol → (+-)-Ethyl-4-(hydroxymethyl)-2-oxazolidinone

HRID 852

반응식

HRID 852 반응식
[NH2:1][C:2](CC)([CH2:5][OH:6])[CH2:3][OH:4].[C:9](=O)(OCC)[O:10]CC.[CH3:17][CH2:18]O>C[O-].[Na+]>[CH2:17]([N:1]1[CH:2]([CH2:3][OH:4])[CH2:5][O:6][C:9]1=[O:10])[CH3:18]

참가 물질

5

반응물 3

HCID 702EthanolHCID 7766Diethyl CarbonateHCID 82822-Amino-2-ethyl-1,3-propanediol

생성물 1

HCID 19694098(+-)-Ethyl-4-(hydroxymethyl)-2-oxazolidinone

시약·촉매·용매 1

HCID 10942334Sodium Methoxide촉매

실험 절차

Sodium methoxide (2.2 g, Aldrich) was added to a solution of 2-amino-2-ethyl-1,3-propanediol (100.0 g, Aldrich) and diethyl carbonate (169.0 g, Aldrich) This solution was refluxed in a Dean Stark apparatus until no more EtOH was collected. The reaction mixture was cooled, added acetone (200 ml) and allowed to stand overnite at room temperature. The resulting suspension was filtered to give 81.0 g of the desired product as a beige solid. 1H NMR consistent with the proposed structure.

후처리

  1. customwas collected
  2. temperatureThe reaction mixture was cooled
  3. additionadded acetone (200 ml)
  4. customto stand overnite at room temperature
  5. filtrationThe resulting suspension was filtered

출처 및 근거

ORD 기록
ord-70a686d8594848a0be625406e5a5cefa
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723458

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