(2-(Benzyloxy)pyridin-4-yl)methanol → 2-(Benzyloxy)isonicotinaldehyde

HRID 852068노트

반응식

HRID 852068 반응식
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([CH2:15][OH:16])[CH:12]=[CH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([CH:12]=[CH:11][N:10]=1)[CH:15]=[O:16])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 16096699(2-(Benzyloxy)pyridin-4-yl)methanol

생성물 1

HCID 229262712-(Benzyloxy)isonicotinaldehyde수율 89.8%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6212Chloroform용매

실험 절차

A suspension of [2-(benzyloxy)-4-pyridyl]methanol (6.0 g) and activated manganese dioxide (30 g) in chloroform (180 mL) was heated under reflux for 2.5 hours. After the reaction solution was allowed to cool to room temperature, the manganese dioxide was filtered off and washed with ethyl acetate. The filtrate was concentrated to give the title compound as a pale brown oil (5.34 g).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 2.5 hours
  3. filtrationthe manganese dioxide was filtered off
  4. washwashed with ethyl acetate
  5. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-17676fa1028d4f38b483ccd90421ca33
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07253178B2

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