2-Chloro-alpha-(3-methoxyphenyl)-3-pyridinemethanol → (2-Chloro-pyridin-3-yl)-(3-methoxy-phenyl)-methanone

HRID 852089

반응식

HRID 852089 반응식
[Cl:1][C:2]1[C:7]([CH:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH3:17])[CH:11]=2)[OH:9])=[CH:6][CH:5]=[CH:4][N:3]=1>[O-2].[Mn+4].[O-2].C1(C)C=CC=CC=1>[Cl:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH3:17])[CH:11]=2)=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1

참가 물질

4

반응물 1

HCID 201457332-Chloro-alpha-(3-methoxyphenyl)-3-pyridinemethanol

생성물 1

HCID 10243711(2-Chloro-pyridin-3-yl)-(3-methoxy-phenyl)-methanone수율 66%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 1140Toluene용매

실험 절차

Combine (2-chloro-pyridin-3-yl)-(3-methoxy-phenyl)-methanol (9.40 g, 37.6 mmol), manganese (IV) oxide (30.0 g, 0.345 mol) and toluene (500 mL) and heat to reflux for one hour. Filter reaction mixture through celite, wash with toluene:dichloromethane mixture and evaporate to give the title compound (1.63 g, 66% Yield).

후처리

  1. temperatureto reflux for one hour
  2. filtrationFilter
  3. customreaction mixture through celite
  4. washwash with toluene
  5. customdichloromethane mixture and evaporate

출처 및 근거

ORD 기록
ord-c911483f263244228b471f1f0eb54e62
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07253165B2

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