Ethanol → (R)-1-[3-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-3-phenethylamino-propan-2-ol

HRID 852149노트

반응식

HRID 852149 반응식
[F:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH2:16][C@H:17]4[CH2:19][O:18]4)[CH:10]=3)=[N:7][O:8][C:4]=2[CH:3]=1.[CH2:22](O)[CH3:23]>ClC(Cl)C.C(N)CC1C=CC=CC=1>[F:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:9]3[CH:10]=[C:11]([CH:12]=[CH:13][CH:14]=3)[O:15][CH2:16][C@H:17]([OH:18])[CH2:19][NH:7][CH2:6][CH2:5][C:23]3[CH:22]=[CH:4][CH:3]=[CH:2][CH:21]=3)=[N:7][O:8][C:4]=2[CH:3]=1

참가 물질

5

반응물 2

HCID 702EthanolHCID 58928264(R)-6-fluoro-3-(3-oxiranylmethoxy-phenyl)-benzo[d]isoxazole

생성물 1

HCID 9909288(R)-1-[3-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-3-phenethylamino-propan-2-ol

시약·촉매·용매 2

HCID 1001Phenethylamine용매HCID 63651,1-Dichloroethane용매

실험 절차

The title compound is prepared from a mixture of (R)-6-fluoro-3-(3-oxiranylmethoxy-phenyl)-benzo[d]isoxazole in dichloroethane, phenethylamine, and ethanol, essentially as described above in Example 57. Purity by LC/MS=˜88%, [M+H]+=407.

출처 및 근거

ORD 기록
ord-f4abccbb043e40d191e946915f326adc
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07253165B2

반응 노트

불러오는 중…