N-cyclohexyl-N-methyl-2-nitrobenzamide → 2-amino-N-cyclohexyl-N-methylbenzamide

HRID 852234노트

반응식

HRID 852234 반응식
[CH:1]1([N:7]([CH3:19])[C:8](=[O:18])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N+:15]([O-])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>CO.[Ni]>[NH2:15][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[C:8]([N:7]([CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)[CH3:19])=[O:18]

참가 물질

4

반응물 1

HCID 799283N-cyclohexyl-N-methyl-2-nitrobenzamide

생성물 1

HCID 8453022-amino-N-cyclohexyl-N-methylbenzamide수율 96%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

A solution of the crude N-cyclohexyl-N-methyl-2-nitrobenzamide (1.05 g, 4 mmol) and a catalytic amount of Raney-Ni® in methanol (25 ml) was stirred overnight under hydrogen at room temperature. The catalyst was removed by filtration and the filtrate was concentrated under reduced pressure. The resulting crude was dissolved in dichloromethane and washed with saturated aqueous sodium bicarbonate. The organic layer was dried (MgSO4) and the solvents removed under reduced pressure to give (0.89 g, 96%) of the title compound as a white solid.

후처리

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. dissolutionThe resulting crude was dissolved in dichloromethane
  4. washwashed with saturated aqueous sodium bicarbonate
  5. dry with materialThe organic layer was dried (MgSO4)
  6. customthe solvents removed under reduced pressure

출처 및 근거

ORD 기록
ord-681d2c642a5d45a682ebb157387e4e2e
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07253171B2

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