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Ammonia → (4-Chlorophenyl)[3-(3-chlorophenyl)-2,1-benzisoxazol-5-yl]methanone

HRID 852275
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인쇄 미리보기

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HRID 852275 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[O:9][N:10]=[C:11]3[CH:16]=[CH:15][C:14]([C:17]4([C:22]5[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=5)OCC[O:18]4)=[CH:13][C:12]=23)[CH:5]=[CH:6][CH:7]=1.N>Cl.CO>[Cl:28][C:25]1[CH:24]=[CH:23][C:22]([C:17]([C:14]2[CH:15]=[CH:16][C:11]3[C:12]([CH:13]=2)=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[O:9][N:10]=3)=[O:18])=[CH:27][CH:26]=1
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참가 물질

5

반응물 2

HCID 222AmmoniaHCID 23248654HCID 23248654, 화합물

생성물 1

HCID 22136476(4-Chlorophenyl)[3-(3-chlorophenyl)-2,1-benzisoxazol-5-yl]methanone수율 93%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 887Methanol용매

반응 조건

온도
100 °C

실험 절차

A mixture of intermediate (6-a) (30 g) in HCl 3 N (220 ml) and methanol (165 ml) was stirred at 100° C. for 5 hours. The mixture was poured into ice and basified with NH3 (aq.). The precipitate was filtered off, washed with water and diethyl ether and dried, yielding 24.9 g (93%) of (4-chlorophenyl)[3-(3-chlorophenyl)-2,1-benzisoxazol-5-yl]methanone (interm. 6-b). The product was used without further purification.

후처리

  1. additionThe mixture was poured into ice
  2. filtrationThe precipitate was filtered off
  3. washwashed with water and diethyl ether
  4. customdried

출처 및 근거

ORD 기록
ord-8ac9a1c97e67435d90bb9779ef7b9255
출처 데이터셋
uspto-grants-2007_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07253183B2

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