Water → HCID 25151661, 화합물

HRID 85235

반응식

HRID 85235 반응식
N[CH:2]([OH:4])[CH3:3].Br[CH2:6][C:7]1[C:8](=[O:36])[N:9]([C:13]2[CH:18]=[CH:17][C:16]([N:19]3[CH2:23][C@H:22]([CH2:24][NH:25][C:26]([C:28]4[S:29][C:30]([Cl:33])=[CH:31][CH:32]=4)=[O:27])[O:21][C:20]3=[O:34])=[CH:15][C:14]=2[CH3:35])[CH:10]=[CH:11][CH:12]=1.O.C[N:39](C=O)C>>[Cl:33][C:30]1[S:29][C:28]([C:26]([NH:25][CH2:24][C@@H:22]2[O:21][C:20](=[O:34])[N:19]([C:16]3[CH:17]=[CH:18][C:13]([N:9]4[CH:10]=[CH:11][CH:12]=[C:7]([CH2:6][NH:39][CH2:3][CH2:2][OH:4])[C:8]4=[O:36])=[C:14]([CH3:35])[CH:15]=3)[CH2:23]2)=[O:27])=[CH:32][CH:31]=1

참가 물질

5

반응물 4

HCID 962WaterHCID 6228DimethylformamideHCID 522583Acetaldehyde ammoniaHCID 59410175HCID 59410175, 화합물

생성물 1

HCID 25151661HCID 25151661, 화합물

실험 절차

At −10° C., 38 mg (0.63 mmol) of aminoethanol are added to a solution of 56 mg (0.11 mmol) of the compound from Example 11A in 1 ml of DMF. After 30 min at −10° C., the mixture is added to water and then extracted three times with ethyl acetate. The organic phases are combined and then freed from the solvent under reduced pressure. The product is purified by preparative HPLC using an acetonitrile/water mixture. This gives 14.5 mg (26% of theory) of the desired product.

후처리

  1. extractionextracted three times with ethyl acetate
  2. customThe product is purified by preparative HPLC

출처 및 근거

ORD 기록
ord-e5c41719a1074ce286fce892844580d6
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846934B2

연결된 노트

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