Diethyl Ether → 4-Hydroxyimino-6-phenyl-hexanoic acid
반응식
O=[C:2]([CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:3][CH2:4][C:5]([OH:7])=[O:6].Cl.[NH2:17][OH:18].C[O-].[Na+].CCOCC>CO>[OH:18][N:17]=[C:2]([CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:3][CH2:4][C:5]([OH:7])=[O:6]참가 물질
6
실험 절차
The ketone 99 (3.0 g, 13.6 mmol) and hydroxylamine hydrochloride (1.98 g, 27 mmol) were dissolved in methanol (20 mL) then sodium methoxide (2.9 g) was added. The solution was stirred and refluxed for 2 hr then cooled. Ether was added and the organic layer was washed twice with 2M HCl, brine and dried over MgSO4. Removal of solvent gave the oximes 100 (2.7 g 90%) as a mixture of E:Z isomers in the ratio 1.5:1.
후처리
- temperaturerefluxed for 2 hr
- temperaturethen cooled
- washthe organic layer was washed twice with 2M HCl, brine
- dry with materialdried over MgSO4
- customRemoval of solvent
출처 및 근거
- ORD 기록
- ord-5353d4ad944d49e7bce5b3d97acdda7e
- 출처 데이터셋
- uspto-grants-2007_08
- 특허 번호
- US07253194B2
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