Sodium Hydroxide → HCID 66621889, 화합물

HRID 852922

반응식

HRID 852922 반응식
[OH-].[Na+].C[O:4][C:5](=[O:21])[C:6]1[CH:11]=[CH:10][C:9]([CH2:12][N:13]2[CH:17]=[C:16]([C:18]#[N:19])[C:15]([NH2:20])=[N:14]2)=[CH:8][CH:7]=1>O.CO>[NH2:20][C:15]1[C:16]([C:18]#[N:19])=[CH:17][N:13]([CH2:12][C:9]2[CH:10]=[CH:11][C:6]([C:5]([OH:21])=[O:4])=[CH:7][CH:8]=2)[N:14]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 666222814-(3-Amino-4-cyano-pyrazol-1-ylmethyl)-benzoic acid methyl ester

생성물 1

HCID 66621889HCID 66621889, 화합물수율 92.4%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

To a solution of NaOH (343 mg, 8.58 mmol) in a mixture of water (10 ml) and MeOH (20 ml) the ester 95 (732 mg, 2.86 mmol) was added. The reaction mixture was refluxed 2 min and stirred for additional 2 hrs at ambient temperature. MeOH was removed under reduced pressure and remaining aqueous solution was acidified with conc. HCl (pH 3-4) to form a precipitate which was collected by filtration to afford the title compound (96) (640 mg, 92% yield). LRMS: 242.2 (calc.), 241.1 (found).

후처리

  1. additionwas added
  2. temperatureThe reaction mixture was refluxed 2 min
  3. customMeOH was removed under reduced pressure
  4. customto form a precipitate which
  5. filtrationwas collected by filtration

출처 및 근거

ORD 기록
ord-dde82f7b0e724dfebac237b078681d02
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07253204B2

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