Hydrochloric Acid → 2-(4-Fluorophenyl)cyclopropane-1-carboxylic acid
반응식
C([O:3][C:4]([CH:6]1[CH2:8][CH:7]1[C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=1)=[O:5])C.O.[Li].CO.Cl>O>[F:15][C:12]1[CH:11]=[CH:10][C:9]([CH:7]2[CH2:8][CH:6]2[C:4]([OH:5])=[O:3])=[CH:14][CH:13]=1참가 물질
6
반응 조건
- 온도
- 80 °C
실험 절차
In a round flask was charged with 2-(4-fluoro-phenyl)-cyclopropanecarboxylic acid ethyl ester (1700 mg, 8.16 mmol), lithium monohydrate (1370 mg, 32.7 mmol), methanol (25 mL) and water (10 mL). The mixture was heated at 80° C. for 2 hours. The reaction mixture was rotavaped. The residue was neutralized with 4N hydrochloric acid and extracted with dichloromethane. The dichloromethane layer was washed with brine, dried over sodium sulfate and evaporated to give 1.61 grams of white solid as desired product. LC-MS m/e 179 (MH−).
후처리
- extractionextracted with dichloromethane
- washThe dichloromethane layer was washed with brine
- dry with materialdried over sodium sulfate
- customevaporated
출처 및 근거
- ORD 기록
- ord-e241415c28f1486b8f59b99aaf1da2ad
- 출처 데이터셋
- uspto-grants-2007_08
- 특허 번호
- US07253285B2
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