Hydrochloric Acid → 2-(4-Fluorophenyl)cyclopropan-1-amine

HRID 853027노트

반응식

HRID 853027 반응식
C(OC(=O)[NH:7][CH:8]1[CH2:10][CH:9]1[C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)(C)(C)C.Cl>O1CCOCC1>[F:17][C:14]1[CH:13]=[CH:12][C:11]([CH:9]2[CH2:10][CH:8]2[NH2:7])=[CH:16][CH:15]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 58615363Carbamic acid, (2-(4-fluorophenyl)cyclopropyl)-, 1,1-dimethylethyl ester

생성물 1

HCID 221749042-(4-Fluorophenyl)cyclopropan-1-amine

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

In a round flask was added [2-(4-fluoro-phenyl)-cyclopropyl]-carbamic acid tert-butyl ester (350 mg) and 4N HCl in 1,4-dioxane (3 mL) for 2 hours. The reaction mixture was concentrated by rotavaping to obtain the crude product of 270 mg as white solid. LC-MS m/e 152 (MH+). The crude product was directly used for next step.

후처리

  1. concentrationThe reaction mixture was concentrated

출처 및 근거

ORD 기록
ord-e13192096bad49ef9e8e840a3898f1dc
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07253285B2

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