4-Nitrophenol → 6-Cyano-7-(2-methoxyethoxy)-4-(4-nitrophenoxy)quinoline

HRID 853214

반응식

HRID 853214 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH2:15][CH2:16][O:17][CH3:18])=[C:9]([C:12]#[N:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.[N+:19]([C:22]1[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=1)([O-:21])=[O:20].N1C(C)=CC=CC=1C>C(OCC)(=O)C>[C:12]([C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:14][CH2:15][CH2:16][O:17][CH3:18])[N:5]=[CH:4][CH:3]=[C:2]2[O:28][C:25]1[CH:26]=[CH:27][C:22]([N+:19]([O-:21])=[O:20])=[CH:23][CH:24]=1)#[N:13]

참가 물질

5

반응물 3

HCID 9804-NitrophenolHCID 79372,6-LutidineHCID 226465224-Chloro-6-cyano-7-(2-methoxyethoxy)quinoline

생성물 1

HCID 229363416-Cyano-7-(2-methoxyethoxy)-4-(4-nitrophenoxy)quinoline수율 43.1%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

반응 조건

온도
155 °C

실험 절차

A mixture of 4-chloro-6-cyano-7-(2-methoxyethoxy)quinoline (3 g), 4-nitrophenol (3.17 g) and 2,6-lutidine (2.7 ml) was heated and stirred in an oil bath at 155° C. for 1.5 hours. After completion of the reaction, ethyl acetate was added, and the precipitated solid was filtered out. The solid was washed with 1N sodium hydroxide water and then with water and dried to obtain 1.8 g of the title compound.

후처리

  1. temperaturewas heated
  2. additionwas added
  3. filtrationthe precipitated solid was filtered out
  4. washThe solid was washed with 1N sodium hydroxide water
  5. dry with materialwith water and dried

출처 및 근거

ORD 기록
ord-5d00d7a841b449c38a8f5e7a2f2bb764
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07253286B2

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