Ammonia → 4-(4-[1,2,3]Triazol-1-ylmethyl-thiazol-2-yl)-phenol

HRID 854680

반응식

HRID 854680 반응식
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:10][CH:11]=[C:12]([CH2:14][N:15]3[CH:19]=[CH:18][N:17]=[N:16]3)[N:13]=2)=[CH:5][CH:4]=1.N>Br>[N:15]1([CH2:14][C:12]2[N:13]=[C:9]([C:6]3[CH:7]=[CH:8][C:3]([OH:2])=[CH:4][CH:5]=3)[S:10][CH:11]=2)[CH:19]=[CH:18][N:17]=[N:16]1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 694293601-[2-(4-methoxy-phenyl)-thiazol-4-ylmethyl]-1H-[1,2,3]triazole

생성물 1

HCID 1363552324-(4-[1,2,3]Triazol-1-ylmethyl-thiazol-2-yl)-phenol수율 22.2%

시약·촉매·용매 1

HCID 260Hydrogen Bromide용매

실험 절차

A solution of 1.36 g (5.0 mmol) 1-[2-(4-methoxy-phenyl)-thiazol-4-ylmethyl]-1H-[1,2,3]triazole in 100 ml 47% aqueous hydrobromic acid was stirred at 70° C. for 6 h. The reaction mixture was poured on ice, made basic with concentrated ammonia and extracted with ethyl acetate to yield 0.87 g raw product. This was purified on silica. Elution with ethyl acetate/heptane 1:1 furnished 287 mg (22%) 4-(4-[1,2,3]triazol-1-ylmethyl-thiazol-2-yl) -phenol as white crystals, melting at 164-166° C.

후처리

  1. additionThe reaction mixture was poured on ice
  2. extractionextracted with ethyl acetate
  3. customto yield 0.87 g raw product
  4. customThis was purified on silica
  5. washElution with ethyl acetate/heptane 1:1

출처 및 근거

ORD 기록
ord-77d0b38999b44f44a34031cf5e3d30e7
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07259262B2

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