Formaldehyde → L-Pantothenic acid

HRID 855485

반응식

HRID 855485 반응식
[C:1]([OH:15])(=[O:14])[CH2:2][CH2:3][NH:4][C:5](=[O:13])[C@@H:6]([C:8]([CH2:11][OH:12])([CH3:10])[CH3:9])[OH:7].CC1(C)C(O)C(=O)OC1.C=O.[C-]#N>>[C:1]([OH:15])(=[O:14])[CH2:2][CH2:3][NH:4][C:5](=[O:13])[C@H:6]([C:8]([CH2:11][OH:12])([CH3:10])[CH3:9])[OH:7]

참가 물질

5

반응물 4

HCID 712FormaldehydeHCID 989(+-)-PantolactoneHCID 5975CyanideHCID 6613Pantothenic Acid

생성물 1

HCID 5748353L-Pantothenic acid

실험 절차

Pantothenic acid can be prepared by chemical synthesis, or biotechnologically by fermentation of suitable microorganisms in suitable nutrient solutions. In the chemical synthesis, DL-pantolactone is an important precursor. It is prepared in a multi-stage process from formaldehyde, isobutylaldehyde and cyanide, and in further process steps, the racemic mixture is separated, D-pantolactone is subjected to a condensation reaction with β-alanine, and D-pantothenic acid is obtained in this way.

후처리

  1. customin further process steps, the racemic mixture is separated
  2. customD-pantolactone is subjected to a condensation reaction with β-alanine

출처 및 근거

ORD 기록
ord-b2a872f85b334f1bb22987ffb947785a
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07262034B2

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