Dichloromethane → 4-(4-Trifluoromethylphenylamino)piperidine-1-carbonylchloride

HRID 856140노트

반응식

HRID 856140 반응식
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:8]=[CH:7][C:6]([NH:9]N2CCCCC2)=[CH:5][CH:4]=1.[Cl:18][C:19](Cl)([O:21]C(=O)OC(Cl)(Cl)Cl)Cl.C([N:32]([CH2:35][CH3:36])[CH2:33][CH3:34])C.[CH2:37](Cl)Cl>>[F:17][C:2]([F:1])([F:16])[C:3]1[CH:4]=[CH:5][C:6]([NH:9][CH:37]2[CH2:34][CH2:33][N:32]([C:19]([Cl:18])=[O:21])[CH2:35][CH2:36]2)=[CH:7][CH:8]=1

참가 물질

5

반응물 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 94429TriphosgeneHCID 23081449(4-Trifluoromethylphenylamino)piperidine

생성물 1

HCID 230810884-(4-Trifluoromethylphenylamino)piperidine-1-carbonylchloride

실험 절차

A mixture of (4-trifluoromethylphenylamino)-piperidine (1.14 g, 4.67 mmol), triphosgene (0.55 g, 1.87 mmol), and triethylamine (0.98 ml, 7.01 mmol) in methylene chloride (10 ml) was stirred at room temperature for 1.5 hours. The reaction mixture was washed with water, and dried over magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure to afford 4-(4-trifluoromethylphenylamino)piperidine-1-carbonylchloride (1.43 g, quantitative) as a pale yellow oil.

후처리

  1. washThe reaction mixture was washed with water
  2. dry with materialdried over magnesium sulfate
  3. filtrationAfter filtration
  4. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-294c295f681641c0bb6a5b434c65f72b
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07262212B2

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