반응식
[CH:1]([S:3]([CH:6]=[CH2:7])(=[O:5])=[O:4])=[CH2:2].[CH2:8](N(CC)CC)C.[NH2:15][CH2:16][CH2:17][CH2:18][NH:19][C@:20]12[CH2:55][CH2:54][C@@H:53]([C:56]([CH3:58])=[CH2:57])[C@@H:21]1[C@@H:22]1[C@@:35]([CH3:38])([CH2:36][CH2:37]2)[C@@:34]2([CH3:39])[C@@H:25]([C@:26]3([CH3:52])[C@@H:31]([CH2:32][CH2:33]2)[C:30]([CH3:41])([CH3:40])[C:29]([C:42]2[CH:51]=[CH:50][C:45]([C:46]([O:48]C)=[O:47])=[CH:44][CH:43]=2)=[CH:28][CH2:27]3)[CH2:24][CH2:23]1>CCO>[CH3:8][C:50]1[CH:51]=[C:42]([C:29]2[C:30]([CH3:40])([CH3:41])[C@H:31]3[C@:26]([CH3:52])([CH2:27][CH:28]=2)[C@@H:25]2[C@:34]([CH3:39])([C@@:35]4([CH3:38])[C@H:22]([CH2:23][CH2:24]2)[C@H:21]2[C@H:53]([C:56]([CH3:58])=[CH2:57])[CH2:54][CH2:55][C@:20]2([NH:19][CH2:18][CH2:17][CH2:16][N:15]2[CH2:7][CH2:6][S:3](=[O:5])(=[O:4])[CH2:1][CH2:2]2)[CH2:37][CH2:36]4)[CH2:33][CH2:32]3)[CH:43]=[CH:44][C:45]=1[C:46]([OH:48])=[O:47]참가 물질
5
반응물 3
생성물 1
시약·촉매·용매 1
반응 조건
- 온도
- 100 °C
실험 절차
Vinylsulfonylethene (5.90 mg, 0.050 mmol) and triethylamine (6.96 μl, 0.050 mmol) were added to a mixture of methyl 4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-(3-aminopropylamino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)benzoate (15 mg, 0.025 mmol) in EtOH (1 mL). The reaction mixture was heated to 100° C. for 3 hours. The reaction mixture was concentrated under reduced pressure to provide the desired product as a brown solid (15 mg, 76%). LCMS: m/e 719.46 (M+H)+, 3.68 min (method 10).
후처리
- concentrationThe reaction mixture was concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-9651d5b1da8f433cb811e2faa8c72009
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08846647B2
연결된 노트
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