Sodium Hydroxide → N-methyl-1-(4-nitrophenyl)methanamine

HRID 856658

반응식

HRID 856658 반응식
[CH3:1][N:2]([CH2:9][C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][CH:11]=1)C(=O)C(F)(F)F.[OH-].[Na+]>CO>[CH3:1][NH:2][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([N+:16]([O-:18])=[O:17])=[CH:14][CH:15]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 21953032N-methyl-N-(4-nitrobenzyl)trifluoroacetoamide

생성물 1

HCID 409440N-methyl-1-(4-nitrophenyl)methanamine수율 90.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of N-methyl-N-(4-nitrobenzyl)trifluoroacetoamide (11.82 g) in methanol (200 ml) was added 1N aqueous solution of sodium hydroxide (50 ml) at room temperature. The mixture was stirred at room temperature for 24 hours, and concentrated under reduced pressure. The mixture was extracted with ethyl acetate and dried over magnesium sulfate. The mixture was concentrated under reduced pressure, to give methyl(4-nitrobenzyl)amine (6.78 g).

후처리

  1. concentrationconcentrated under reduced pressure
  2. extractionThe mixture was extracted with ethyl acetate
  3. dry with materialdried over magnesium sulfate
  4. concentrationThe mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-28bdd760140a41e99235eed51e855ef0
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07262185B2

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