Water → (2-Methylpyridin-3-yl)methanol

HRID 856704

반응식

HRID 856704 반응식
[H-].[Li+].[Al+3].[H-].[H-].[H-].[CH3:7][C:8]1[N:17]=[CH:16][CH:15]=[CH:14][C:9]=1[C:10](OC)=[O:11].O.[OH-].[Na+]>C1COCC1>[CH3:7][C:8]1[C:9]([CH2:10][OH:11])=[CH:14][CH:15]=[CH:16][N:17]=1

참가 물질

6

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 7015327Methyl 2-methylnicotinateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 302564(2-Methylpyridin-3-yl)methanol수율 70.6%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a solution of aluminum lithium hydride (2.0 g) in THF (160 ml) was added dropwise a solution of methyl 2-methylnicotinate (8.0 g) in THF (80 ml) at 0° C. The mixture was stirred for 2 hours at room temperature, and water (8.0 ml), 15% aqueous solution of sodium hydroxide (8.0 ml) and water (24.0 ml) were sequentially added to the mixture at 0° C. The mixture was filtered with Celite, and washed with methanol. The solvent was removed under reduced pressure, and the obtained residue was purified by silica gel column chromatography, to give (2-methyl-3-pyridinyl)methanol (4.6 g).

후처리

  1. filtrationThe mixture was filtered with Celite
  2. washwashed with methanol
  3. customThe solvent was removed under reduced pressure
  4. customthe obtained residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-2a9563f0cf564642a63a6036f515f015
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07262185B2

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