Water → 7-Benzyloxy-6-methoxy-3,4-dihydro-2H-naphthalen-1-one

HRID 856807

반응식

HRID 856807 반응식
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][CH2:8][C:9]2=[O:12])=[CH:4][C:3]=1[O:13][CH3:14].[CH2:15](Br)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.C([O-])([O-])=O.[K+].[K+].O>CC(C)=O>[CH2:15]([O:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][CH2:8][C:9]2=[O:12])=[CH:4][C:3]=1[O:13][CH3:14])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 3168407-Hydroxy-6-methoxy-1-tetralone

생성물 1

HCID 218627167-Benzyloxy-6-methoxy-3,4-dihydro-2H-naphthalen-1-one수율 62.8%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 4.5 g (0.0233 mole) of 7-hydroxy-6-methoxy-1-tetralone, 5.4 g (0.032 mole) of benzyl bromide and 10 g (0.072 mole) of K2CO3 in 150 ml of acetone was heated to reflux overnight. The reaction as cooled, poured into water and extracted with EtOAc. The EtOAc was dried over Na2SO4 and evaporated to give 7 g of crude product. Crystallization with Et2O gave 4.13 g of product as a white solid, mp 110-111° C.

후처리

  1. temperaturewas heated
  2. temperatureto reflux overnight
  3. customThe reaction
  4. temperatureas cooled
  5. extractionextracted with EtOAc
  6. dry with materialThe EtOAc was dried over Na2SO4
  7. customevaporated
  8. customto give 7 g of crude product
  9. customCrystallization with Et2O

출처 및 근거

ORD 기록
ord-2be790c6a8a041b4bc60d9a2b9a17b3d
출처 데이터셋
uspto-grants-2006_12
특허 번호
USRE039419E1

연결된 노트

불러오는 중…